@article {2673,
	title = {Two-Phase Synthesis of Taxol},
	journal = {Journal of the American Chemical Society},
	volume = {142},
	year = {2020},
	month = {Oct-06-2020},
	pages = {10526 - 10533},
	abstract = {Taxol (a brand name for paclitaxel) is widely regarded as among the most famed natural isolates ever discovered, and has been the subject of innumerable studies in both basic and applied science. Its documented success as an anticancer agent, coupled with early concerns over supply, stimulated a furious worldwide effort from chemists to provide a solution for its preparation through total synthesis. Those pioneering studies proved the feasibility of retrosynthetically guided access to synthetic Taxol, albeit in minute quantities and with enormous effort. In practice, all medicinal chemistry efforts and eventual commercialization have relied upon natural (plant material) or biosynthetically derived (synthetic biology) supplies. Here we show how a complementary divergent synthetic approach that is holistically patterned off of biosynthetic machinery for terpene synthesis can be used to arrive at Taxol.},
	keywords = {1ST TOTAL-SYNTHESIS, ANALOGS, chemistry, DIMETHYLDIOXIRANE, ENANTIOSELECTIVE TOTAL-SYNTHESIS, FORMAL TOTAL-SYNTHESIS, PINENE PATH, RING, STEREOCONTROLLED SYNTHESIS, TAXANES},
	issn = {0002-7863},
	doi = {10.1021/jacs.0c0359210.1021/jacs.0c03592.s00110.1021/jacs.0c03592.s002},
	url = {https://pubs.acs.org/doi/10.1021/jacs.0c03592},
	author = {Kanda, Yuzuru and Nakamura, Hugh and Umemiya, Shigenobu and Puthukanoori, Ravi Kumar and Murthy Appala, Venkata Ramana and Gaddamanugu, Gopi Krishna and Paraselli, Bheema Rao and Baran, Phil S.}
}
@article {2118,
	title = {Volcanic gases, black smokers, and the Great Oxidation Event},
	journal = {Geochimica Et Cosmochimica Acta},
	volume = {66},
	year = {2002},
	note = {608ztTimes Cited:295
Cited References Count:57
},
	month = {Nov},
	pages = {3811-3826},
	abstract = {This paper proposes that gradual changes in the composition of volatiles that have been added to the atmosphere-ocean system are responsible for the Great Oxidation Event (G.O.E.) ca. 2.3 Ga. Before ca. 2.3 Ga, the composition of these volatiles was probably such that 20\% of the carbon gases could be reduced to organic matter and all of the sulfur gases could be reduced to pyrite. Since 2.3 Ga, the composition of these volatiles has been such that 20\% of the carbon gases could be reduced to organic matter, but only a fraction of the sulfur gases could be reduced to pyrite. This change led to the oxygenation of the atmosphere and to a large increase in the SO4-2 concentration of seawater. A considerable body of observational data supports these proposals. Copyright (C) 2002 Elsevier Science Ltd.},
	keywords = {atmospheric oxygen, carbon, chemistry, east pacific rise, evolution, hydrothermal vent fluids, midocean ridges, precambrian cherts, south-africa, sulfur cycle},
	isbn = {0016-7037},
	doi = {10.1016/S0016-7037(02)00950-X},
	author = {Holland, H. D.}
}
